Scientists said Sunday they had uncovered 5 genes linked to the onset of Alzheimer's disease, doubling the number of genetic variants known to favor the commonest form of dementia.
The findings, published in the journal Nature Genetics, may provide clues on the causes of this incurable and complex disease and help doctors predict who is most at risk, they said.
In the largest such studies to date, some 300 scientists in two consortia combed the genomes of 54,000 people -- some afflicted, others not -- to tease out the newly identified genetic variations.
The two projects started out independently but later swapped their data, enabling each group to confirm the overall findings.
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