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Eplerenone, How Does it Work, DrugDigest.org:"Eplerenone works by blocking aldosterone, a chemical that causes water and salt retention that can increase blood pressure. By blocking aldosterone, eplerenone causes the kidneys to get rid of unneeded water and salt from the body in the urine."
Expresscripts.com
Burstyn, Lance
521 Alton Rd #208, Miami Beach, FL 33140, US
http://www.drugdigest.org/******************************************************
Eplerenone, Indications and Warnings, eDrugInfo.com:"Contraindicated in patients who are allergic to eplerenone or hyperkalemic (potassium level greater than 5.5 mEq/L); also contraindicated in those with type 2 diabetes with microalbuminuria, in those with creatinine clearance less than 50 ml/minute), and in those with creatinine level greater than 2 mg/dl in men or 1.8 mg/dl in women. Also contraindicated in patients taking potassium supplements or potassium-sparing diuretics, ketoconazole, or itraconazole.
Use cautiously in patients with hepatic impairment. Use cautiously also in pregnant and breast-feeding patients."
Lippincott Williams & Wilkins
P.O. Box 1600, Hagerstown, MD 21741, USA.
In the US, dial 1 (800) 638-3030 http://www.lww.com/******************************************************
Eplerenone, Drugs and Foods to Avoid, Genesis Health System:"Make sure your doctor knows if you are also using erythromycin (Erythro-Tab), verapamil (Calan), saquinavir (Fortovase), fluconazole (Diflucan), lithium, blood pressure medicine (such as Accupril, Altace, Avapro, Cozaar, Diovan, Hyzaar, Lotensin, Lotrel, Monopril, Prinivil, Vasotec, Zestril), or pain or arthritis medicine (such as ibuprofen, Advil, Aleve, Daypro, Motrin, Orudis, Relafen).
Do not take any medicine with potassium while you are using eplerenone. This includes salt substitutes and some vitamin or mineral supplements."
Genesis Health System
1227 E. Rusholme Street, Davenport, IA 52803
563-421-1000
http://www.genesishealth.com/******************************************************
Eplerenone (Systemic), Pregnancy, MEDLINEplus:"Eplerenone has not been studied in pregnant women. Before taking this medicine, make sure that your healthcare professional knows if you are pregnant or if you may become pregnant.
Breast-feeding-It is not known whether eplerenone passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their healthcare professional.
Children-Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of eplerenone in children with use in other age groups."
Office of Communications and Public Liaison
National Library of Medicine
8600 Rockville Pike Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450 email: publicinfo@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/******************************************************
Eplerenone, Mechanism of Action, MosbysDrugConsult.com:"Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g., kidney) and nonepithelial (e.g., heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms.
Eplerenone has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effect of eplerenone on blood pressure.
Eplerenone has relative selectivity in binding to recombinant human mineralocorticoid receptors compared to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."
Elsevier, Health Sciences Division
11830 Westline Industrial Drive, St. Louis, MO 63146
1-800-545-2522 http://www.us.elsevierhealth.com/******************************************************
Using eplerenone (Inspra), Dear Patient, NursingDrugGuide.com:"Your health care provider has prescribed the antihypertensive drug eplerenone to treat your hypertension. This drug works by blocking the effects of aldosterone, a hormone normally found in your body. The results of this block may be an increase in urination and an increase in serum potassium levels. The name of this drug is Inspra."
Lippincott Williams & Wilkins
P.O. Box 1600, Hagerstown, MD 21741, USA.
In the US, dial 1 (800) 638-3030 http://www.lww.com/******************************************************
Eplerenone, Indications and Dosage, RxLIst.com:"INSPRA is indicated for the treatment of hyper-tension. INSPRA may be used alone or in combination with other antihypertensive agents.
INSPRA may be used alone or in combination with other antihypertensive agents. The recommended starting dose of INSPRA is 50 mg administered once daily. The full therapeutic effect of INSPRA is apparent within 4 weeks. For patients with an inadequate blood pressure response to 50mg once daily the dosage of INSPRA should be increased to 50 mg twice daily. Higher dosages of INSPRA are not recommended either because they have no greater effect on blood pressure than 100 mg or because they are associated with an increased risk of hyperkalemia. (See CLINICAL STUDIES .) No adjustment of the starting dose is recommended for the elderly or for patients with mild-to-moderate hepatic impairment. For patients receiving weak CYP3A4 inhibitors, such as erythro-mycin, saquinavir, verapamil, and fluconazole the starting dose should be reduced to 25 mg once daily (see CONTRAINDICATIONS)."
RxList - The Internet Drug Index: Searchable drug database. RxList LLC
500 3rd Street Suite 530
San Francisco, CA 94107
707-747-0985 fax: 708 575 8638
info@rxlist.com
http://www.rxlist.com/******************************************************
Eplerenone, How should this medicine be used, SafeMedication.com:"Eplerenone comes as a tablet to take by mouth. It is usually taken once or twice a day, with or without food. To help you remember to take eplerenone, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eplerenone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor may start you on a low dose of eplerenone and increase your dose after 4 weeks.
Eplerenone controls high blood pressure but does not cure it. It may take 4 weeks or longer before you feel the full benefit of eplerenone. Continue to take eplerenone even if you feel well. Do not stop taking eplerenone without talking to your doctor."
American Society of Health-System Pharmacists
7272 Wisconsin Avenue Bethesda, MD 20814
301-657-3000
http://www.safemedication.com/******************************************************
Eplerenone, What is eplerenone, Web Md Health:"Eplerenone blocks the actions of the hormone aldosterone in the body. Aldosterone is important for the regulation of blood pressure.
Eplerenone is used to lower high blood pressure.
Eplerenone may also be used for purposes other than those listed in this medication guide.
WebMD
1175 Peachtree Road, NE, Suite 2400, Atlanta, GA 30361.
212-624-3700service@webmd.net
http://my.webmd.com/content/drugs/******************************************************
Eplerenone, What happens if I miss a dose, YaleNewHavenHealth.org:"Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose."
Yale New Haven Health System
789 Howard Avenue, New Haven, CT 06519
Tel.(203)688-4608, Fax (203)688-3774
http://yalenewhavenhealth.org/******************************************************
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