Crohn's Disease Basics & Overview | Healthline

What Is Crohn's Disease?

By the Healthline Editorial Team
Reviewed by Jennifer Monti, MD, MPH

     

Crohn’s disease is a chronic condition that causes inflammation, swelling, and deep sores called ulcers in the body’s gastrointestinal (GI) tract (commonly called the digestive tract). Although it can involve any part of the GI tract from the mouth to the anus, Crohn’s disease most often affects the lower portion of the small intestine (the ileum) and the upper portion of the large intestine (the colon).

Crohn’s disease is similar to another chronic inflammatory condition that affects only the colon—ulcerative colitis. These diseases are part of a larger group of illnesses called inflammatory bowel disease (IBD).

Both Crohn’s disease and ulcerative colitis fluctuate between periods of remission (inactivity) and relapse (increased activity). Neither have a medical cure, but medical and alternative therapies can reduce the symptoms that people with Crohn’s disease and ulcerative colitis experience during times of relapse. In many cases, these therapies help people maintain a normal lifestyle with few interruptions from the diseases.

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Probiotic bacteria could help treat Crohn's disease, American Society for Microbiology

New research suggests that infection with a probiotic strain of E. coli bacteria could help treat an reduce the negative effects of another E. coli infection that may be associated with Crohn's disease. Researchrs from the University of Auckland, New Zealand publish their results in the April 2011 issue of the journal Applied and Environmental Microbiology.

Crohn's disease is a common chronic disorder that affects the gastrointestinal tract and is believed to develop as a result of an aberrant immune response to intestinal microbes in a genetically susceptible host. Over the last decade, high levels of adherent invasive E. coli (AIEC) have been reported. One study isolated the bacteria in 36% of Crohn's sufferers compared to just 6% of controls.

Since Crohn's disease is a clinical subtype of inflammatory bowel disease (IBD) and others have reported successful treatment of IBC with the probiotic E. coli Nissle 1917 (EcN), the researchers investigated the impact EcN might have on an already established infection with AIEC in cell cultures mimicking those found in the lining of the intestines.

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Inflammatory Bowel Disease Raises Clot Risk

Inflammatory bowel disease may more than double the risk of a serious blood clot in the legs or lungs, according to a new study.

Inflammatory bowel disease (IBD) is an umbrella term that includes a variety of intestinal disorders, such as Crohn’s disease and ulcerative colitis.

Researchers found that children and adults with IBD were more than twice as likely to develop a dangerous type of blood clot that develops in the leg, known as deep vein thrombosis (DVT), or lung, called pulmonary embolism (PE).

These types of blood clots affect about two out of every 1,000 people in developed countries each year, and the risk generally increases with age.

But in this study, researchers found the results showed the relative risk of blood clots associated with IBD was particularly high among young people.

In people aged 20 and younger, the relative risk of a pulmonary embolism was six times higher among people with inflammatory bowel disease, compared to similarly aged people without IBD.

via webmd.com

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