Probiotic bacteria could help treat Crohn's disease, American Society for Microbiology

New research suggests that infection with a probiotic strain of E. coli bacteria could help treat an reduce the negative effects of another E. coli infection that may be associated with Crohn's disease. Researchrs from the University of Auckland, New Zealand publish their results in the April 2011 issue of the journal Applied and Environmental Microbiology.

Crohn's disease is a common chronic disorder that affects the gastrointestinal tract and is believed to develop as a result of an aberrant immune response to intestinal microbes in a genetically susceptible host. Over the last decade, high levels of adherent invasive E. coli (AIEC) have been reported. One study isolated the bacteria in 36% of Crohn's sufferers compared to just 6% of controls.

Since Crohn's disease is a clinical subtype of inflammatory bowel disease (IBD) and others have reported successful treatment of IBC with the probiotic E. coli Nissle 1917 (EcN), the researchers investigated the impact EcN might have on an already established infection with AIEC in cell cultures mimicking those found in the lining of the intestines.

via eurekalert.org

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13 Surprising Causes Of Constipation

Read More: Cause Of Constipation, Causes Of Constipation, Constipation, Constipation Cause, Constipation Causes, Constipation Troubles, Personal Health, Slidepollajax, What Causes Constipation, Health News

What causes constipation? Well, the obvious culprits include a low fiber diet, repeatedly ignoring the urge to go, not drinking enough water, or a lack of exercise.

But constipation also has other, less-well-known causes, including certain medications and supplements, as well as potentially serious medical conditions.

What's causing your gut trouble? Here are 13 possible causes of constipation you may not have considered.

1 of 13

Hypothyroidism

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Hypothyroidism, or an underactive thyroid gland, slows the body's metabolic processes -- even the gut. Not everyone with an underactive thyroid has constipation, nor do all cases of constipation mean that the butterfly-shaped gland in your neck is underperforming. Still, "when I see a young person who's constipated more than normal and really complaining, I do tend to get a thyroid level," says Carla H. Ginsburg, M.D., assistant professor of medicine at Harvard Medical School in Boston. More from Health.com: Quick Cures for Tummy Troubles 10 Risk Factors for IBD 13 Reasons for Bladder Trouble

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Hypothyroidism, or an underactive thyroid gland, slows the body's metabolic processes -- even the gut.

Not everyone with an underactive thyroid has constipation, nor do all cases of constipation mean that the butterfly-shaped gland in your neck is underperforming.

Still, "when I see a young person who's constipated more than normal and really complaining, I do tend to get a thyroid level," says Carla H. Ginsburg, M.D., assistant professor of medicine at Harvard Medical School in Boston.

via huffingtonpost.com

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Medical News: FDA Panel Says Okay to Lower BMI for Lap-Band - in Primary Care, Obesity from MedPage Today

An FDA advisory committee voted 8 to 2 that Allergan's Lap-Band device is safe enough to use in patients with a BMI as low as 30.

The stomach-shrinking device is currently approved for weight loss in people who are at least 100 pounds overweight or have a body mass index (BMI) of at least 40, or a BMI of at least 35 with other comorbidities such as heart disease.

Allergan is looking for approval to lower those BMI cutoffs to 35 and 30 respectively.

If the FDA follows the advice of its advisory committee the Lap-Band could be an option for another 27 million Americans.

The Lap-Band is an adjustable silicon band that is implanted through tiny incisions around the upper stomach. It works by reducing stomach capacity and thus the amount of food the stomach can hold. Its use involves a less invasive procedure than gastric bypass or stomach stapling, but it is also less effective, FDA reviewers noted in briefing documents released in advance of Friday's meeting.

The FDA's Gastroenterology and Urology Devices Panel spent Friday discussing Allergan's single-arm study of 143 patients with the lower BMI criteria.

All 143 had significant reductions in weight and BMI after one year, with only 37% still meeting the criteria for obesity.

After one year, eight out of 10 Lap-Band recipients lost at least 30% of their excess weight, and 66% lost at least half.

via medpagetoday.com

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